PRCC-TFE3 tRCC: Cell Line Data on Mitophagy and Proliferation

Bo Wang from the Canadian Institute for Advanced Research produced this dataset. It contains experimental observations from a PRCC-TFE3 translocation renal cell carcinoma cell line, focusing on mitophagy, transcriptional control, and cell survival under mitochondrial oxidative damage. The dataset is available via the paperswithcode platform under an Open Access (green) license.

Use Cases

• Modeling the relationship between PRCC-TFE3 fusion protein and PINK1-PRKN-dependent mitophagy based on described experimental observations.
• Analyzing the role of PRKN/parkin expression in cancer cell survival under mitochondrial oxidative damage based on the described mechanisms.
• Investigating the transcriptional control of PPARGC1A/PGC1α-NRF1 on mitochondrial turnover as described in the study.

Strengths

• Dataset is derived from a specific, defined PRCC-TFE3 translocation renal cell carcinoma cell line.
• The description details a focused biological mechanism involving PRCC-TFE3 fusion, mitophagy, and cell proliferation.

Limitations

• Row count and dataset size are unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• Last update date is unknown; freshness unverified.

Provenance

Source

paperswithcode

Collection Method

Likely contains experimental results from cell line studies as described in the associated research.