Preclinical Assessment of a CAIX-Targeted PET Probe for Renal Cancer Imaging

A preclinical dataset from figshare, authored by You Cheng and last updated in May 2026, details the evaluation of a sulfur(VI) fluoride exchange-modified PET probe for imaging clear cell renal cell carcinoma. The data likely contains quantitative results from in vitro and in vivo studies, including affinity measurements (IC50 values), internalization rates, and biodistribution metrics in mice and cynomolgus monkeys. The 848-byte CSV file suggests a small, focused dataset summarizing key experimental findings.

Use Cases

• Compare tumor uptake and off-target biodistribution of novel PET tracers based on the reported percentage injected dose per gram (%ID/g) values.
• Analyze the impact of chemical modifications (SuFEx) on probe affinity and internalization using the provided IC50 and internalization percentage data.
• Evaluate tumor-to-background contrast ratios, such as tumor-to-stomach, to assess imaging probe performance.
• Support the design of future CAIX-targeted imaging agents or radionuclide therapies based on preclinical efficacy and specificity results.

Strengths

• Includes specific quantitative metrics: IC50 values of 7.53 nM and 4.60 nM for probe affinity comparison.
• Reports concrete performance improvements: a tumor-to-stomach ratio increase from 1.21 to 32.69 for the modified probe.
• Data is derived from multiple experimental models: in vitro studies, OS-RC-2 tumor-bearing mice, and cynomolgus monkey PET/CT imaging.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is very small (848 bytes), indicating it is likely a summary table rather than raw experimental data.

Provenance

Source

figshare, author You Cheng.

Collection Method

Likely compiled from laboratory experiments in preclinical radiopharmaceutical research.

Time Range

Temporal coverage of the underlying experiments is not specified.

Freshness

Last updated 2026-05 19:39:55; freshness should be verified.

Geography

Spatial coverage is not specified.