Pediatric Sepsis Biomarker Data for Organ Dysfunction Prognosis

A retrospective study of 150 children with sepsis admitted to a pediatric intensive care unit in China. Heparin-binding protein and routine inflammatory markers were measured within 24 and 48 hours of admission. The data was used to assess prognostic performance for outcomes including organ dysfunction progression, illness severity, and 28-day mortality.

Use Cases

• Predicting organ dysfunction progression based on heparin-binding protein levels.
• Assessing illness severity based on biomarker trajectories over 48 hours.
• Evaluating the need for organ support therapies like mechanical ventilation or renal replacement.
• Comparing prognostic performance of heparin-binding protein against conventional inflammatory biomarkers.

Strengths

• Includes serial biomarker measurements at two time points (within 24h and ~48h) for 150 patients.
• Links biomarker data to multiple clinical outcomes: organ dysfunction, severity, support requirements, and 28-day mortality.
• Prognostic performance was assessed using multiple statistical methods including ROC analysis and multivariable regression.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• Data is from a single-center study, which may limit generalizability.

Provenance

Source

People’s Hospital of Guangxi Zhuang Autonomous Region, China.

Collection Method

Single-center retrospective observational study.

Freshness

Last updated 2026-06-02 11:59:39; freshness should be verified.

Geography

China.