Plumbagin-Loaded Lipid Nanoparticle Characterization and In Vivo Evaluation

Yongqi Peng published experimental data on figshare in May 2026 detailing the preparation and evaluation of a lipid cubic liquid crystal nano-drug delivery system for plumbagin. The dataset includes characterization metrics like particle size (203.50 nm), zeta potential (-39.51 mV), encapsulation efficiency (80.21%), and drug loading (5.66%), alongside in vitro release and in vivo pharmacokinetic results. The study demonstrates a 295.58% relative oral bioavailability for the nanoparticle formulation compared to free drug.

Use Cases

• Modeling drug release kinetics based on the Weibull equation parameters described for in vitro release.
• Optimizing nanoparticle formulation parameters using the described Box-Behnken response surface methodology (BBD-RSM).
• Comparing oral bioavailability enhancement for nano-formulated drugs based on the reported 295.58% relative bioavailability metric.
• Analyzing relationships between nanoparticle characteristics (size, zeta potential) and encapsulation efficiency/drug loading outcomes.

Strengths

• Provides specific, quantitative characterization data including particle size (203.50 nm), zeta potential (-39.51 mV), encapsulation efficiency (80.21%), and drug loading (5.66%).
• Includes comparative in vivo pharmacokinetic results showing a 295.58% relative oral bioavailability for the nanoparticle formulation.
• Documents a clear methodological approach using single-factor tests and Box-Behnken response surface methodology for optimization.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for statistical modeling.
• The dataset is small (22.1 MB), which may constrain the scope of analysis.

Provenance

Source

Yongqi Peng via figshare

Collection Method

Experimental data from preparation, optimization, in vitro release testing, and in vivo pharmacokinetic/small animal imaging studies.

Time Range

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Freshness

Last updated 2026-05 17:27:43; freshness should be verified.

Geography

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