Probing Immune Signatures of Conjugated Pattern Recognition Receptor Ligands

A dataset from figshare by Špela Janež, last updated May 2026. It contains results from a phenotypic screen of chimeric pattern recognition receptor (PRR) ligands in human peripheral blood mononuclear cells. The data likely includes measurements of cytokine signatures and cytotoxic immune activity for different conjugate combinations.

Use Cases

• Identifying potent adjuvant candidates based on cytokine signature profiles.
• Comparing immune activation levels between conjugated and unconjugated PRR ligand mixtures.
• Screening for antitumor activity based on in vitro cytotoxic immune activity data.
• Analyzing the relationship between specific receptor combinations (e.g., TLR4/TLR7) and immune response outcomes.

Strengths

• Data is from a focused panel of defined pairwise agonist combinations targeting selected PRRs.
• Includes results from both in vitro human cell screening and in vivo murine vaccination models.
• File size is 1.4 KB, indicating a compact and focused dataset.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• Description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

figshare

Collection Method

Phenotypic screening in human peripheral blood mononuclear cells and murine models.

Freshness

Last updated 2026-05-06 05:44:07; freshness should be verified.