Endogenous Opioid Peptide Release from Adrenal Chromaffin Cells

Jenna M. Berger's dataset profiles the release kinetics and chemical diversity of opioid peptides from adrenal chromaffin cells. The data was generated using a workflow integrating real-time electrochemical detection and liquid chromatography–mass spectrometry (LC–MS). The dataset was last updated on 2026-05-06.

Use Cases

• Analyzing the temporal complexity of enkephalin release kinetics based on fast-scan cyclic voltammetry data.
• Profiling the chemical diversity of proenkephalin-derived peptides based on LC–MS data mentioned in the description.
• Comparing the co-release of catecholamines and opioid peptides from large dense-core vesicles.
• Investigating the release of extended M-ENK variants like YGGFM-RF and BAM-22 in response to stimulation.

Strengths

• Data integrates two analytical techniques: real-time electrochemical detection and tandem mass spectrometry.
• Dataset includes measurements from single chromaffin cells, providing single-cell resolution.
• File size is 1.3 MB, indicating a focused and likely manageable dataset.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• Description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

figshare

Collection Method

Experimental workflow integrating fast-scan cyclic voltammetry and liquid chromatography–mass spectrometry (LC–MS).

Freshness

Last updated 2026-05-06 11:03:26; freshness should be verified.