Prokineticin 2 Expression and Trophoblast Function in Preeclampsia

A 142.5 KB dataset contains experimental results investigating the role of prokineticin 2 (PK2) in preeclampsia pathogenesis. It includes data from immunohistochemistry, ELISA assays on patient and mouse model samples, and transcriptomic analysis of PK2-treated trophoblast cells. The dataset was authored by Ying Li and uploaded to figshare in April 2026.

Use Cases

• Analyze PK2 and PKR2 protein expression levels from immunohistochemistry data to compare preeclampsia patients with normal controls.
• Correlate quantified PK2 levels from ELISA assays with clinical outcomes in patient and mouse model samples.
• Identify differentially expressed genes (e.g., EGR1, FOS, JUN, CCN1, CCN2) from transcriptomic analysis of PK2-treated trophoblast cells.
• Model the impact of recombinant PK2 protein on trophoblast proliferation and migration metrics from functional assays.
• Investigate enrichment of stress-response and inflammatory pathways from the PK2-induced gene set data.

Strengths

• Data includes results from multiple experimental methods: immunohistochemistry, ELISA, and transcriptomic analysis.
• Findings are validated across human patient samples and a mouse model of preeclampsia.
• Dataset is openly shared under a CC-BY-4.0 license.

Limitations

• The dataset is small at 142.5 KB, indicating limited scope and likely a small sample size.
• Specific row counts, column names, and sample sizes for patient and control groups are not provided.
• Data is derived from a single study, limiting generalizability.

Provenance

Source

figshare, authored by Ying Li.

Collection Method

Experimental data from immunohistochemistry, ELISA assays on placental samples, and transcriptomic analysis of a trophoblast cell line.

Freshness

Data was last updated in April 2026.