Promiscuity Cliffs and Hubs Formed by Human Kinase Inhibitors

A collection of promiscuity cliffs (PCs), promiscuity cliff pathways (PCPs), and promiscuity hubs (PHs) formed by kinase inhibitors, covering more than 80% of the human kinome. The data structures were introduced for analyzing compound promiscuity and are provided by Filip Miljković from the University of Bonn. The dataset is referenced in multiple published research articles.

Use Cases

• Identify promiscuous kinase inhibitors based on the provided PC, PCP, and PH structures.
• Analyze relationships between compound structure and multi-kinase activity using the promiscuity cliff data.
• Model kinase inhibitor selectivity profiles across the human kinome.
• Validate computational methods for predicting compound promiscuity against this experimental dataset.

Strengths

• Covers more than 80% of the human kinome.
• Based on published research and peer-reviewed methodology.
• Provides multiple related data structures (PCs, PCPs, PHs) for analysis.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Last update date is unknown; freshness unverified.

Provenance

Source

University of Bonn

Collection Method

Computational analysis of kinase inhibitors, as described in referenced publications.