PROMISE 1077AP: Antepartum Cohort Trial for HIV Transmission Prevention

3490 primarily black African HIV-infected pregnant women were enrolled at a median of 26 weeks gestation in a randomized trial comparing antiretroviral therapy regimens. The dataset, created by the IMPAACT Statistical and Data Analysis Center, shows a 0.5% transmission rate with ART versus 1.8% with zidovudine alone, but higher risks of adverse maternal and neonatal outcomes.

Use Cases

• Compare the efficacy of different antiretroviral regimens for preventing mother-to-child HIV transmission based on the trial's primary outcome.
• Analyze the safety profiles of zidovudine-based versus tenofovir-based ART based on reported maternal adverse event and abnormal blood chemical value rates.
• Investigate the association between antiretroviral therapy and low birth weight incidence based on the reported frequency of births under 2500g.
• Model risk-benefit trade-offs for HIV treatment in pregnant women with high CD4 counts based on the trial's transmission and safety results.

Strengths

• Data originates from a large randomized trial involving 3490 participants, providing a substantial sample size.
• Includes specific, quantified primary outcomes: HIV transmission rates (0.5% vs 1.8%) and maternal adverse event rates (21.1% vs 17.3%).
• Trial design details are explicitly provided, including enrollment criteria (CD4 count ≥350 cells/mm³ at ≥14 weeks gestation) and compared treatment arms.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for specific analytical tasks.
• The dataset is 19.4 MB in size, which is relatively small and may indicate limited granularity or a focus on summary results.

Provenance

Source

IMPAACT Statistical and Data Analysis Center

Collection Method

Randomized clinical trial (PROMISE 1077AP Antepartum Cohort)

Time Range

The trial enrolled women at a median of 26 weeks gestation; specific study years are not provided.

Freshness

Last updated 2026-03-18 16:51:23; freshness should be verified.

Geography

Primarily black African populations in resource-limited countries; specific countries are not listed.