Propranolol and NDV in Canine Mammary Tumor: In Vitro and Xenograft Data

Newcastle disease virus, an oncolytic agent, activates the interferon response that limits its own replication in canine mammary tumor cells. Experimental data from the CMT-U27 cell line and xenograft model shows propranolol suppresses this antiviral JAK-STAT pathway, enhancing viral replication and oncolysis. This dataset likely contains results from cell viability, migration, invasion, and viral load assays supporting the combination therapy hypothesis.

Use Cases

• Analyzing drug-virus synergy based on cell viability and viral replication data.
• Modeling tumor growth inhibition based on xenograft model results.
• Investigating JAK-STAT pathway modulation based on interferon signaling measurements.
• Comparing treatment efficacy of monotherapy versus combination therapy.

Strengths

• Dataset is openly licensed under CC-BY-4.0, permitting reuse and redistribution.
• Cross-platform presence on figshare indicates established sharing and potential importance.
• The study design includes both in vitro (CMT-U27 cell line) and in vivo (xenograft model) experimental layers.

Limitations

• Column names and row counts are not provided, limiting understanding of data structure.
• Metadata is sparse, lacking information on the organization responsible for the research.
• The dataset size (2,025,663 bytes) suggests it contains files, but the specific content of XLSX and DOCX files is unknown.

Provenance

Source

Yunjie Zhu

Collection Method

Experimental data from in vitro assays using the CMT-U27 canine mammary tumor cell line and an in vivo CMT-U27 xenograft model.

Time Range

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Freshness

Last updated on 2026-03 23.

Geography

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