GMAS-01: Herbal Extract Effects on Oxidative Stress in SH-SY5Y Cells

A research dataset from figshare details the protective effects of the GMAS-01 herbal formulation against hydrogen peroxide–induced oxidative stress in SH-SY5Y neuroblastoma cells. The dataset, authored by Muhammad Awais and last updated in May 2026, includes HPLC analysis, molecular docking results, and measurements of cell viability, apoptosis, and antioxidant enzyme activities. It is a small 82.0 KB document shared under a CC-BY-4.0 license.

Use Cases

• Evaluating the neuroprotective potential of herbal compounds based on cell viability and apoptosis assays.
• Studying molecular interactions of bioactive compounds like catechin and acanthoside D with apoptosis-related targets.
• Analyzing the modulation of antioxidant enzyme activities (SOD, GPx, CAT) and ROS generation under oxidative stress.
• Investigating the suppression of NF-κB signaling pathways in a cellular model of neurodegeneration.

Strengths

• Includes specific molecular docking results for compounds binding to targets like NF-κB, APP, Bax, Bcl-2, caspase-3, and caspase-9.
• Reports quantitative measurements from multiple assays: cell viability, mitochondrial membrane potential, ROS generation, and antioxidant enzyme activities.
• Identifies three major bioactive compounds (catechin, p-coumaric acid, acanthoside D) via HPLC analysis.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The dataset is very small at 82.0 KB, indicating limited scope.

Provenance

Source

figshare

Collection Method

Experimental study involving cell culture, HPLC analysis, molecular docking, and gene expression analysis.

Freshness

Last updated 2026-05-28 18:16:06; freshness should be verified.