Human and Mouse Protein Kinase Inhibitors with Activity Measurements

A deposition of data sets for human and mouse protein kinase inhibitors assembled from public repositories. It contains compounds with reliable activity measurements and corresponding inactive compounds. The data was assembled by Elena Xerxa of the University of Bonn, with the human inhibitors analyzed in a 2023 Journal of Medicinal Chemistry publication.

Use Cases

• Predicting compound bioactivity based on assembled activity measurements.
• Training classification models to distinguish active from inactive kinase inhibitors.
• Analyzing trends in covalent protein kinase inhibitor design as referenced in the 2023 publication.

Strengths

• Includes both active and inactive compound classifications, which is useful for model training.
• Data is assembled from public repositories, suggesting a degree of curation and integration.
• Human protein kinase inhibitors have been analyzed in a peer-reviewed 2023 publication.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Last update date is unknown; freshness unverified.

Provenance

Source

Assembled from public repositories by Elena Xerxa, University of Bonn.

Collection Method

Data assembled from public repositories; specific methods are not detailed.