Proteomic Features of Brain Structures in a Mouse Model of Affective Disorders

A 2026 study by L. Smirnova provides proteomic data from three brain structures in a Disc1-Q31L-/- mouse model of affective disorders. Over 1,000 unique proteins were identified across the prefrontal cortex, hippocampus, and hypothalamus using mass spectrometry. The dataset, shared under a CC-BY-4.0 license, is 7.7 GB in size.

Use Cases

• Identify protein expression differences in brain regions based on the over 1,000 unique proteins identified.
• Analyze signaling pathways involved in neurotransmitter systems and immune responses based on the 39, 22, and 38 specific pathways reported.
• Investigate the role of proteins involved in 'binding' and 'catalytic activity' in the context of affective disorders.
• Validate findings from the Disc1-Q31L-/- mouse model against other models of neuropsychiatric conditions.

Strengths

• Identifies over 1,000 unique proteins across three brain structures.
• Reports 39, 22, and 38 specific signaling pathways for the prefrontal cortex, hippocampus, and hypothalamus, respectively.
• Data is shared under a permissive CC-BY-4.0 license.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data is derived from a specific mouse model (Disc1-Q31L-/-), which may limit generalizability.

Provenance

Source

L. Smirnova via figshare

Collection Method

Mass spectrometry analysis of brain tissue from a Disc1-Q31L-/- mouse model.

Freshness

Last updated 2026-06-01 11:27:13; freshness should be verified.