Ketamine Under Propofol Sedation Trial Protocol and Pilot Results

Theresa R. Lii published a protocol and pilot results for a randomized controlled trial on 2026-04-16. The dataset includes a 108.2 KB DOCX file describing a trial of 42 adults with chronic pain and depression, testing ketamine versus placebo under propofol sedation. Six pilot participants completed the study, which is registered under NCT06317636.

Use Cases

• Designing a blinding protocol for psychoactive drug trials based on the described propofol sedation method.
• Analyzing patient blinding efficacy based on the pilot's post-sedation and subsequent allocation guesses.
• Planning outcome measures for chronic pain trials based on the primary outcome of daily pain intensity change.
• Assessing safety and feasibility of a combined sedation and infusion procedure for clinical research.

Strengths

• Protocol is for a double-blind, randomized, placebo-controlled trial, a gold-standard design.
• Pilot results include data from 6 participants with specific metrics like 5/6 immediate post-sedation guesses.
• Dataset is openly licensed under CC-BY-4.0.

Limitations

• Dataset is a 108.2 KB text document; the underlying clinical data (rows, columns) is not included.
• Column-level documentation is absent; field semantics must be inferred from the protocol description.
• The trial's full results with 42 participants are not yet available in this dataset.

Provenance

Source

Theresa R. Lii via figshare

Collection Method

Clinical trial protocol and pilot study results.

Freshness

Last updated 2026-04-16 10:21:31

Geography

Single-center trial (location unspecified).