Mouse Splenic Transcriptome Data on Age and Proton Irradiation Effects

Transcriptome analysis was performed on splenic tissue from adolescent (68 day) versus old (736 day) C57BL/6 male mice injected with Lewis lung carcinoma cells, with or without three fractionations of 0.5Gy proton irradiation. The dataset was created by the National Aeronautics and Space Administration and last updated on March 13, 2026. It investigates host tissue alterations with age and whole-body proton exposure, focusing on signaling changes related to carcinogenesis.

Use Cases

• Modeling age-dependent immune response to proton irradiation based on transcriptome data.
• Identifying key regulatory genes like CDK2 and MCM7 involved in carcinogenesis support.
• Comparing host environment responses in adolescent versus old subjects as described.
• Studying the biological component of proton irradiation operative through host age.

Strengths

• Specific age groups are defined (68-day adolescent and 736-day old mice).
• Experimental conditions are clearly described (Lewis lung carcinoma cells, 0.5Gy proton irradiation).
• Key regulatory genes implicated in the response are named (CDK2, MCM7, CD74, RUVBL2).

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data is stored in a BIN format, which may require specialized tools for access.

Provenance

Source

National Aeronautics and Space Administration

Collection Method

Transcriptome analysis performed on splenic tissue from tumor-bearing mice.

Time Range

Experimental timeframe is not specified.

Freshness

Last updated 2026-03-13 19:18:27.214367; freshness should be verified.

Geography

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