LRP2-APEX2 Mouse Kidney Protein Interaction Data

Protein interaction data from an Lrp2-APEX2-expressing mouse model, identifying cytoplasmic partners of the LRP2 receptor via in vivo biotinylation. The dataset was created by Tian H. Shen and last updated on April 20, 2026. It likely contains mass spectrometry results from kidney lysate.

Use Cases

• Identify novel protein interactions with LRP2 based on biotinylation data.
• Study the role of PDZ domain proteins in apical membrane organization.
• Analyze changes in endocytic regulators and molecular motors in the absence of LRP2.
• Validate the specificity and sensitivity of the APEX2 labeling technique for protein interaction mapping.

Strengths

• Dataset is based on an engineered mouse model for in vivo labeling, suggesting biological relevance.
• The description indicates identification of both known and novel endocytic regulators.
• Data is available in an XLSX format (2.2 MB), which is accessible for analysis.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data may reflect the specific experimental conditions of the mouse model.

Provenance

Source

figshare

Collection Method

In vivo biotinylation of Lrp2-APEX2-expressing mice followed by mass spectrometry and immunostaining.

Freshness

Last updated 2026-04-20 18:08:54; freshness should be verified.