LRP2-APEX2: Protein Interaction Data from Mouse Kidney Lysate

LRP2-APEX2-expressing mice were engineered to label cytoplasmic partners of the Lrp2 receptor. Biotinylated proteins from kidney lysate were identified via mass spectrometry and immunostaining. The dataset likely contains proteins functionally associated with endocytosis, including regulators and molecular motors.

Use Cases

• Identify novel protein interactions with Lrp2 based on biotinylation data.
• Analyze the role of PDZ domain proteins in apical membrane organization.
• Investigate the linkage between Lrp2 and fluid-phase endocytosis regulators.
• Compare protein interaction profiles in Lrp2-expressing versus Lrp2-deficient models.

Strengths

• Data generated from a specific engineered mouse model (LRP2-APEX2-expressing mice).
• Protein identification performed via mass spectrometry and immunostaining, suggesting experimental validation.
• The dataset is 44.4 KB, indicating a focused and manageable size for analysis.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Data may reflect the specific experimental conditions of the mouse model.

Provenance

Source

figshare

Collection Method

Biotinylation in vivo followed by mass spectrometric identification and immunostaining.

Freshness

Last updated 2026-04-20 18:08:56; freshness should be verified.