92 clinical trials of psychological and pharmacological treatments for adults with severe PTSD, with patient mean ages generally in the 30s to 40s, were included in this meta-analysis. The dataset was compiled by RTI International from sources including MEDLINE, PsycINFO, and Cochrane Library, covering literature from January 1980 to May 2012.
Use Cases
- Compare effect sizes of different PTSD treatments based on reported Cohen's d and CAPS score reductions.
- Analyze network meta-analysis results for comparative medication effectiveness based on the 28-trial subset.
- Evaluate the strength of evidence (SOE) ratings across various treatment modalities and outcomes.
- Assess the number needed to treat (NNT) for loss of diagnosis across therapies like exposure therapy and CPT.
Strengths
- Analysis includes 92 trials, providing a substantial evidence base.
- Reports specific quantitative outcomes like Cohen's d effect sizes and CAPS score point reductions.
- Employs a graded strength of evidence (SOE) framework based on established guidance.
- Includes a network meta-analysis of 28 trials (4,817 subjects) for comparative medication effectiveness.
Limitations
- Row count and column-level documentation are unknown, limiting suitability assessment.
- Data coverage ends in May 2012; freshness is unverified for current treatment guidelines.
- The description notes insufficient evidence to compare treatments head-to-head or for specific trauma types.
Provenance
- Source
- RTI International, authored by Daniel E Jonas.
- Collection Method
- Systematic review and meta-analysis; two investigators independently selected, extracted data from, and rated risk of bias of relevant trials.
- Time Range
- January 1980 to May 2012.
- Freshness
- Data sources cover January 1980 to May 2012; last update date is unknown.
- Geography
- null