Ming-Yue Wu's research identifies PTK2/FAK kinase inhibitors as potent autophagy inducers via a non-classical mechanism. The 101.4 MB dataset includes DOCX and GIF files describing high-content screening and mechanistic investigations. This work provides new insights for developing targeted therapies against pancreatic ductal adenocarcinoma.
Use Cases
- Analyzing the role of PTK2/FAK inhibition in triggering autophagy flux based on the described screening platform.
- Investigating TMED9-mediated protective autophagy in pancreatic cancer cell survival based on the described functional studies.
- Studying the spatial redistribution of ER exit sites (ERES) following kinase inhibitor treatment based on the described mechanistic investigations.
- Exploring AKAP13 as a novel FAKi-responsive protein based on the described dephosphorylation findings.
Strengths
- Dataset size is 101.4 MB, indicating substantial content.
- License is CC-BY-4.0, allowing for open sharing and reuse.
- Last updated date is provided (2026-05-18).
Limitations
- Column-level documentation is absent; field semantics must be inferred after download.
- Row count is unknown, which may limit suitability assessment.
- Sample data is unavailable, preventing preview of data structure.
Provenance
- Source
- figshare
- Collection Method
- High-content screening using a kinase inhibitor library and subsequent mechanistic investigations.
- Freshness
- Last updated 2026-05-18 05:00:12; freshness should be verified.