Harmonized GWAS Summary Statistics for 114 Traits

114 publicly available GWAS traits harmonized and imputed to the GTEx v8 variant reference. The dataset includes metadata on traits, publication links, consortia, sample sizes, and population ancestry. It was prepared by Alvaro Barbeira at the University of Chicago.

Use Cases

• Conducting cross-trait genetic correlation analyses based on harmonized summary statistics.
• Prioritizing candidate genes for complex diseases based on imputed variant associations.
• Studying population-specific genetic effects based on the provided ancestry metadata.
• Validating new statistical methods for GWAS using a standardized reference set.

Strengths

• Includes 114 distinct GWAS traits.
• Metadata provides sample sizes, population ancestry, and publication links for each trait.
• Data is harmonized and imputed to a common reference (GTEx v8).

Limitations

• Description metadata is limited; actual data quality requires manual inspection after download.
• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.

Provenance

Source

University of Chicago

Collection Method

Harmonization and imputation of publicly available GWAS summary statistics.