Placental Cytokine/Chemokine qPCR Data from Dexamethasone-Treated Humanized Mice

Quantitative PCR data from a study examining transcript level alterations in placental cytokines and chemokines following prenatal dexamethasone exposure. Noriko Nakamura published this dataset on figshare in April 2026 under a CC-BY-4.0 license. The data was generated from humanized mice injected with dexamethasone or saline on gestation days 10–14, with placentae collected on day 18.

Use Cases

• Analyze the impact of dexamethasone on inflammatory marker expression based on qPCR transcript levels.
• Model gene expression profiles in a humanized mouse placenta based on the described experimental treatment.
• Correlate prenatal drug exposure with placental cytokine/chemokine changes based on the described dosing regimen.

Strengths

• Data is derived from a controlled experiment with a defined dexamethasone dose (5 mg/kg) and injection schedule (gestation days 10–14).
• Includes primer pair information, cDNA synthesis method, and qPCR conditions as noted in the description.
• Released under a permissive CC-BY-4.0 license, facilitating reuse.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The sample size per group is relatively small (n = 3–5).

Provenance

Source

figshare, author Noriko Nakamura.

Collection Method

Experimental data from quantitative PCR analysis and histology performed on placentae from humanized mice.

Time Range

The experiment was conducted over a specific gestation period (days 10-18).

Freshness

Last updated 2026-04-03 20:27:51; freshness should be verified.

Geography

Laboratory study; geographic coverage is not specified.