605.6 KB of phosphopeptide-level differential abundance results from quantitative mass spectrometry comparing PKN2 cardiomyocyte-specific knockout and control embryonic mouse hearts. The dataset, authored by Julijus Bogomolovas and last updated in May 2026, includes phosphosite identifiers, protein annotations, fold-change estimates, and statistical significance values.
Use Cases
- Identify phosphorylation sites significantly altered by PKN2 knockout based on p-values and fold-change ratios.
- Analyze protein kinase signaling pathways in embryonic hearts based on annotated phosphoproteins.
- Validate statistical models for phosphoproteomics differential abundance based on TMT-based LC-MS/MS quantification.
Strengths
- Dataset includes both raw and adjusted p-values (cKO_vs_Control_p.val, cKO_vs_Control_p.adj) for statistical rigor.
- Provides mean-centered normalized abundance values for control and cKO samples (Control_centered, cKO_centered).
- Contains unique identifiers combining UniProt accession and phosphorylation site (ID).
Limitations
- Row count is unknown, which may limit suitability assessment.
- Description metadata is limited; actual data quality requires manual inspection after download.
Provenance
- Source
- figshare
- Collection Method
- TMT-based LC-MS/MS quantitative mass spectrometry and statistical modeling of normalized reporter ion intensities.
- Freshness
- Last updated 2026-05-05 20:56:45; freshness should be verified.