Quercitrin Effects on Platelet Activation and Arterial Thrombosis

A biomedical research dataset from a study investigating the anti-thrombotic effects of the flavonoid quercitrin. The study, authored by Hyun Ju from the Korea Institute of Oriental Medicine, assessed platelet aggregation, signaling pathways, and in vivo thrombosis models. Results indicate quercitrin inhibits platelet activation and arterial thrombus formation without prolonging bleeding time.

Use Cases

• Analyze concentration-dependent inhibition of platelet aggregation based on experimental results.
• Model the impact of quercitrin on GPVI- or U46619-mediated phosphorylation signaling pathways.
• Evaluate the correlation between anti-oxidant effects and phosphorylation of the TRAF4/p47phox/Hic5 axis.
• Assess in vivo antithrombotic efficacy using FeCl3-induced arterial thrombus formation data.
• Compare therapeutic potential against stroke based on reduced infarct volume in ischemia/reperfusion models.

Strengths

• Study includes multiple experimental approaches: platelet aggregation, granule secretion, calcium mobilization, integrin activation, and western blot analysis.
• In vivo validation performed using FeCl3-induced arterial thrombus formation and a mouse model of stroke.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Last update date is unknown; freshness unverified.

Provenance

Source

Korea Institute of Oriental Medicine

Collection Method

Experimental laboratory study using platelet function assays and mouse models.