Rapid Optimization: Single-Molecule Tracking Data for a Potent RUVBL1/2 Inhibitor

A 1.9 KB CSV dataset from figshare, authored by Li Zheng and last updated on 2026-04-22. The data likely contains results from a Single-Molecule Tracking (SMT)-driven drug discovery campaign that identified a potent RUVBL1/2 inhibitor, compound 18, for targeting MYC-driven cancers.

Use Cases

• Benchmarking live-cell assay performance based on the described robustness and reproducibility of the RUVBL SMT assay
• Analyzing structure-activity relationships (SAR) based on the SMT-driven optimization campaign mentioned in the description
• Comparing inhibitor efficacy based on the reported correlation between SMT measurements, cell viability, and MYC degradation
• Evaluating xenograft model outcomes based on the improved efficacy of compound 18 in a Burkitt lymphoma model

Strengths

• Data is associated with a published drug discovery campaign that yielded a potent inhibitor, compound 18.
• The underlying SMT assay is described as providing robust and reproducible potency measurements.
• The dataset is small (1.9 KB), facilitating quick inspection and download.

Limitations

• Row count and column-level documentation are unknown, which limits suitability assessment.
• The dataset's 1.9 KB size suggests it contains summary or key results, not the full experimental raw data.

Provenance

Source

figshare, author Li Zheng.

Collection Method

Likely generated from a Single-Molecule Tracking (SMT)-driven drug discovery SAR campaign.

Time Range

null

Freshness

Last updated 2026-04-22 15:07:07; freshness should be verified.

Geography

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