C52: CSF1R Inhibitor Structures for Acute Liver Injury Treatment

A dataset from figshare by Xue Yuan, last updated in April 2026, containing structural data for a series of colony-stimulating factor 1 receptor (CSF1R) inhibitors. The data, stored in PDB format, supports research into compounds like C52, which was shown to inhibit CSF1R, reduce serum transaminase levels, and suppress inflammatory signaling in an acute liver injury model. The dataset size is 520.9 KB.

Use Cases

• Training predictive models for CSF1R inhibitor potency based on structural features.
• Analyzing kinome-wide selectivity profiles of candidate compounds.
• Studying structure-activity relationships for compounds targeting acute liver injury.

Strengths

• Includes data for a specific, potent compound (C52) with demonstrated in vitro and in vivo efficacy.
• Data is associated with a clear, structure-guided optimization strategy described in the source material.
• File format (PDB) is a standard for representing 3D molecular structures.

Limitations

• Row count and specific column-level documentation are unknown, limiting suitability assessment.
• The dataset is small (520.9 KB), indicating a limited scope of molecular structures.

Provenance

Source

figshare, author Xue Yuan.

Collection Method

Likely generated through computational chemistry and experimental validation as part of a drug discovery project.

Freshness

Last updated 2026-04-23 19:34:55.