Hyperglycemia Effects on Periodontal Tissue Adiponectin in a Diabetic Rat Model

Raw experimental data from a study investigating hyperglycemia's impact on the perivascular niche in periodontal ligaments and pulp tissue. The dataset includes quantitative immunohistochemistry, immunofluorescence, RT-qPCR gene expression, and alkaline phosphatase activity measurements from a streptozotocin-induced diabetic rat model and in vitro cell cultures. It was authored by Naoto Ohkura and last updated on 2026-04-17.

Use Cases

• Reproducing statistical analyses based on the quantitative immunohistochemistry and immunofluorescence data for adiponectin, α-SMA, and TGF-β1.
• Validating gene expression findings based on RT-qPCR data for markers related to bone formation, adipogenesis, and remodeling.
• Comparing alkaline phosphatase (ALP) activity measurements between experimental conditions.
• Conducting meta-analyses on perivascular niche dynamics using the provided experimental replication data.

Strengths

• Dataset is 88.5 KB, facilitating quick download and inspection.
• Includes raw data underlying all figures, supporting transparency and reproducibility.
• Covers multiple experimental modalities: immunohistochemistry, gene expression, and enzyme activity.
• Released under a CC0-1.0 license, allowing for unrestricted reuse.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• Data may reflect experimental bias inherent to the specific rat model and cell culture systems used.

Provenance

Source

figshare, authored by Naoto Ohkura.

Collection Method

Data generated from a streptozotocin-induced diabetic rat model and in vitro cell culture systems.

Time Range

Experimental timeframe not specified.

Freshness

Last updated 2026 04 17 08:40:08; freshness should be verified.

Geography

Geographic origin of the study not specified.