RBM45 Protein-RNA Binding Simulations for m6A Recognition

Molecular dynamics simulation data for RNA-binding motif protein 45 (RBM45) interacting with RNA sequences. The dataset, created by Raeyeon Park and last updated in May 2026, provides structural insights into how RBM45 preferentially binds N6-methyladenosine (m6A)-modified RNA motifs over unmodified ones. Simulations investigate binding with GACG, GACU, and GACA RNA motifs in complex with individual RRM domains and the full-length protein.

Use Cases

• Analyzing protein-RNA binding dynamics based on molecular dynamics simulations.
• Investigating the role of m6A modification in RNA-protein recognition based on described GAC motif interactions.
• Studying domain synergy in RNA-binding proteins based on the described cooperation between RRM3, C-terminal, and linker domains.

Strengths

• Data is derived from molecular dynamics simulations, providing atomistic-level biophysical insights.
• The study provides mechanistic insights into m6A preferential binding, a topic noted as a first in the description.
• File size is 34.6 MB, indicating a focused and potentially manageable dataset for analysis.

Limitations

• Row count is unknown, which may limit suitability assessment for certain analyses.
• Column-level documentation is absent; field semantics must be inferred after download.
• Data may reflect the specific simulation conditions and model biases inherent to the study.

Provenance

Source

figshare, author Raeyeon Park

Collection Method

Generated via molecular dynamics simulations.

Freshness

Last updated 2026-05-15 06:30:19