RBM45 Protein-RNA Binding Simulations for m6A Recognition

Molecular dynamics simulations investigate the binding of RNA-binding motif protein 45 (RBM45) to unmodified and N6-methyladenosine (m6A)-modified RNA motifs. The dataset, created by Raeyeon Park and last updated in May 2026, contains 17.3 MB of simulation data in PDB format. It provides biophysical insights into how RRM domains, particularly RRM3, synergize with other protein regions for preferential m6A binding.

Use Cases

• Analyze protein-RNA interaction dynamics based on molecular dynamics simulations of GAC-containing RNA motifs.
• Study the structural basis for preferential m6A binding based on simulations of full-length RBM45 protein.
• Investigate domain synergy in RNA recognition based on comparisons of individual RRM domains versus the full protein context.
• Model the stabilizing effect of the m6A methyl group on RNA-protein complexes and inter-domain interactions.

Strengths

• Simulation data is 17.3 MB in size, providing detailed structural models.
• The study is described as providing the first mechanistic insights into how an RRM domain preferentially recognizes m6A in synergy with other domains.
• Data is available in the structured PDB format, commonly used for molecular structures.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• The description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

figshare

Collection Method

Generated via molecular dynamics (MD) simulations of RNA-protein complexes.

Freshness

Last updated 2026-05-15 06:30:21; freshness should be verified.