RBM45 Preferential Binding to m6A: Molecular Dynamics Simulation Trajectories

Raeyeon Park published molecular dynamics simulation data on 2026-05-15 to investigate RNA-binding motif protein 45 (RBM45). The dataset, 34.6 MB in size, contains PDB files from simulations of RBM45's RRM domains binding to unmodified and m6A-modified RNA motifs. The study provides biophysical insights into how full-length RBM45 preferentially recognizes m6A over adenine.

Use Cases

• Analyzing protein-RNA binding dynamics based on molecular dynamics simulation trajectories.
• Studying the structural impact of m6A RNA modification on protein domain interactions.
• Investigating the synergistic role of linker and C-terminal domains in RNA recognition.
• Validating computational models of RNA-binding motif (RRM) protein function.

Strengths

• Dataset size is 34.6 MB, providing a focused set of simulation data.
• Simulations comply with previous experimental findings, as stated in the description.
• Data format is PDB, a standard for structural biology data.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.

Provenance

Source

Raeyeon Park via figshare

Collection Method

Generated via molecular dynamics (MD) simulations of RNA-protein complexes.

Freshness

Last updated 2026-05-15 06:30:17; freshness should be verified.