RBM45 Protein-RNA Binding Simulations Suggesting Synergy of RRM3 and Other Domains

Molecular dynamics simulation data investigates the binding of RNA-binding motif protein 45 (RBM45) to unmodified and m6A-modified RNA motifs. The dataset, created by Raeyeon Park and last updated in May 2026, includes simulations of RNA complexes with individual RRM domains and with RRM3 in the context of the full-length protein. It provides biophysical insights into how RBM45 preferentially recognizes m6A-modified motifs through domain synergy.

Use Cases

• Analyze protein-RNA binding dynamics based on molecular dynamics simulations of GAC-containing RNA motifs.
• Investigate the role of domain synergy in m6A recognition based on simulations of full-length RBM45.
• Study the structural impact of m6A modification on RNA-protein complex stability based on described interaction analyses.
• Compare binding affinities for different RNA motifs (GACG, GACU, GACA) based on the simulation results described.

Strengths

• Dataset size is 17.3 MB, indicating a focused and manageable download.
• The description provides detailed biophysical insights into the binding mechanisms of RBM45.
• The data is associated with a specific research study and author, providing clear provenance.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for certain analyses.
• The data format (PDB) requires specialized software for visualization and analysis.

Provenance

Source

figshare

Collection Method

Generated via molecular dynamics simulations as described in the associated study.

Freshness

Last updated 2026-05-15 06:30:23