Real-World Sequential Treatment Patterns for Advanced Gastric Cancer in Japan

11,276 patients diagnosed with advanced gastric cancer in Japan between September 2021 and September 2024 were analyzed for treatment patterns and time-to-treatment discontinuation. The dataset captures real-world clinical practice following the 2021 approval of first-line nivolumab, detailing the most common regimens across first, second, and third lines of therapy. It enables analysis of outcomes for different patient groups, including HER2-positive and HER2-negative cohorts treated with various chemotherapy and immunotherapy combinations.

Use Cases

• Comparing time-to-treatment discontinuation across first-line regimens (e.g., nivolumab+chemotherapy vs. chemotherapy alone)
• Analyzing the prevalence of specific drug combinations like nivolumab+S-1+oxaliplatin as a first-line treatment
• Evaluating real-world adherence to Japanese Gastric Cancer Association treatment guidelines after a major therapy approval
• Studying sequential therapy patterns, such as the use of ramucirumab+paclitaxel following first-line immunotherapy

Strengths

• Large-scale cohort of 11,276 patients provides substantial statistical power for subgroup analyses.
• Captures a defined, recent time period (September 2021 to September 2024) relevant to a major treatment guideline change.
• Includes detailed, quantified treatment patterns (e.g., 36.4% received nivolumab+S-1+oxaliplatin first-line) and median time-to-treatment discontinuation outcomes.

Limitations

• Column names and specific data schema are not provided in the available metadata, limiting understanding of the data structure.
• The dataset is derived from a single database (Medical Data Vision), which may not be fully representative of the entire Japanese population.
• Relies on retrospective, observational data which is subject to biases inherent in such study designs.

Provenance

Source

Medical Data Vision database.

Collection Method

Retrospective observational study.

Time Range

September 2021 to September 2024.

Freshness

Last updated on 2026-03-24.

Geography

Japan.