Genotype D1.1 A(H5N1) Influenza Virus Receptor-Binding Data

British Columbia data details the receptor-binding specificity and antigenic properties of a genotype D1.1 A(H5N1) influenza virus isolated from a human case. The study enriched HA-variant subpopulations and assessed sialic acid receptor usage via glycan microarray, solid-phase assays, and biolayer interferometry. All tested variants bound exclusively to avian-type receptors, and their antigenicity was covered by candidate vaccine viruses.

Use Cases

• Analyze sialic acid receptor-binding specificity from glycan microarray and solid-phase assay results to assess avian vs. human receptor tropism.
• Evaluate antigenic properties of enriched HA-variant subpopulations against candidate vaccine viruses.
• Study the potential for human adaptation of genotype D1.1 A(H5N1) viruses based on HÀ substitution data.
• Cross-reference biolayer interferometry binding data with results from other assay methods for validation.

Strengths

• Data is derived from a specific, severe human infection case of genotype D1.1 A(H5N1) in British Columbia.
• Analysis employs multiple experimental methods: glycan microarray, solid-phase assays, and biolayer interferometry.
• Dataset is licensed under CC BY 4.0 for open reuse.

Limitations

• Dataset is very small at 74.1 KB, likely containing summary-level experimental results rather than raw, high-volume data.
• No columnar or sample data is provided, limiting direct analytical utility without contacting the author.
• Primary data format is DOCX, which is not structured for computational analysis and requires manual extraction.

Provenance

Source

figshare, authored by Ahmed Kandeil.

Collection Method

Experimental analysis of an isolated virus via glycan microarray, solid-phase assays, and biolayer interferometry.

Time Range

null

Freshness

Last updated March 2026.

Geography

Virus isolated from a human case in British Columbia, Canada.