Reference intervals for reproductive hormones in Chinese children aged 0–14 years based on

The Paediatric Reference Intervals in China (PRINCE) study provides reference intervals for six reproductive hormones in Chinese children. It includes data from 1,707 healthy children (819 males, 888 females) aged 0–14 years, with intervals stratified by age and sex. Ying Liu published this dataset on figshare in April 2026 under a CC-BY-4.0 license.

Use Cases

• Establishing clinical diagnostic thresholds for paediatric endocrine disorders based on age- and sex-specific hormone reference intervals.
• Modeling hormonal development trajectories based on described surges in testosterone, oestradiol, and follicle-stimulating hormone.
• Validating laboratory test results for reproductive hormones in Chinese paediatric populations.
• Studying pubertal transition markers based on described age-specific hormonal changes.

Strengths

• Includes data from 1,707 healthy children, providing a substantial sample size for reference interval calculation.
• Reference intervals are validated using 280 independent samples.
• Intervals are stratified by distinct age and sex partitions, as described.
• Covers six key reproductive hormones: luteinizing hormone, follicle-stimulating hormone, testosterone, oestradiol, progesterone, and prolactin.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count for the underlying data tables is unknown, which may limit suitability assessment.
• Data reflects a specific Chinese paediatric population, which may limit generalizability to other demographics.

Provenance

Source

figshare, author Ying Liu.

Collection Method

Serum samples collected from the PRINCE cohort of healthy children and adolescents, analyzed using a non-parametric method per Clinical and Laboratory Standards Institute guidelines.

Time Range

Study period not specified; dataset reflects children aged 0–14 years.

Freshness

Last updated 2026-04-11 06:18:31; freshness should be verified.

Geography

China.