Electrochemical and Cytotoxicity Data for 11 Synthetic Thionaphthoquinones

A dataset from paperswithcode presents electrochemical and cytotoxicity data for eleven synthetic 3-thio-substituted-nor-beta-lapachone derivatives. The data includes first wave reduction potentials and cytotoxic activity against several cancer cell lines and one normal cell, with four compounds being novel. Author Yen G. de Paiva contributed this research, which investigates the relationship between electrochemical parameters and anti-cancer activity.

Use Cases

• Modeling the relationship between electrochemical reduction potential and cytotoxic activity based on the described trend for compounds with potentials less negative than -0.65 V.
• Screening for selective anti-cancer compounds based on cytotoxicity data against cancer versus normal cell lines mentioned in the description.
• Investigating mechanisms of action related to reactive oxygen species (ROS) release, as suggested for the highlighted compound 2.
• Comparing the electrophilicity and cytotoxicity of different thio-substituents, as indicated by the analysis of the cyclohexyl derivative.

Strengths

• Includes data for eleven distinct synthetic compounds, with four being novel.
• Provides electrochemical parameters (e.g., first wave reduction potential) alongside biological activity (cytotoxicity) data.
• Reports cytotoxic activity against several cancer cell lines and one normal cell, allowing for selectivity assessment.

Limitations

• Row count and specific column-level documentation are unknown, which may limit suitability assessment.
• Last update date is unknown; freshness unverified.
• The description notes an absence of a linear correlation between electrochemical parameters and cytotoxicity, suggesting complex relationships.

Provenance

Source

paperswithcode

Collection Method

Experimental investigation using electrochemical methods and cytotoxicity assays, as described.