Spirocyclic Analogues of Bupivacaine: Toxicity and Pharmacokinetic Data

A pharmacology dataset from figshare, authored by Alexander A. Kirichok and last updated in May 2026. It contains data on the synthesis and testing of spirocyclic analogues of the local anesthetic bupivacaine. The study measured lethal doses, local anesthetic efficacy in mice, and cardiotoxicity in guinea pig hearts.

Use Cases

• Comparing the cardiotoxicity of drug analogues based on reported lethal dose increases and QRS widening data.
• Analyzing structure-activity relationships for local anesthetics based on the replacement of a piperidine ring with spirocyclic scaffolds.
• Modeling pharmacokinetic distribution based on relative affinity data for plasma, brain, and heart tissues.
• Screening candidate compounds for reduced systemic toxicity using the reported in vivo mouse model results.

Strengths

• Includes specific quantitative results, such as 1.3-, 2.2-, and 5.0-fold increases in lethal doses for three tested structures.
• Data is derived from multiple experimental models, including mice for anesthesia/toxicity and isolated guinea pig hearts for cardiotoxicity.
• Primary data files are provided in the Crystallographic Information File (CIF) format, which is a structured standard.

Limitations

• Row count and column-level documentation are unknown, which limits suitability assessment for computational analysis.
• The dataset is small (1.0 MB), suggesting it may contain summary results rather than raw experimental records.
• Data may reflect bias inherent to the specific in vivo and ex vivo models used in the study.

Provenance

Source

figshare

Collection Method

Experimental research involving synthesis of drug analogues and testing in animal models.

Freshness

Last updated 2026-05-08 13:37:05; freshness should be verified.