CHMI-SIKA Study: Treg and IL-10 Immune Responses in Semi-Immune Kenyan Adults

A replication dataset for a secondary analysis of the CHMI-SIKA study, authored by Kelvin Muteru Kimenyi and last updated on 2026-04-13. The data likely contains immunological measurements from a controlled human malaria infection trial involving semi-immune Kenyan adults. It is hosted on the Biosciences Dataverse.

Use Cases

• Modeling the relationship between baseline Treg frequency and clinical outcomes based on the study's focus.
• Analyzing Treg-associated immune checkpoint responses during infection as described in the manuscript.
• Investigating plasma IL-10 response patterns in semi-immune adults mentioned in the dataset title.
• Validating immunological findings from controlled human malaria infection (CHMI) studies.

Strengths

• Dataset is a direct replication package for a peer-reviewed manuscript, ensuring traceability.
• Last update timestamp of 2026-04-13 08:51:45 is provided.

Limitations

• Row count, column definitions, and file formats are unknown, limiting suitability assessment.
• Description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

Biosciences Dataverse

Collection Method

Collected during the Controlled Human Malaria Infection - SIKA (CHMI-SIKA) clinical study.

Time Range

Temporal coverage of the underlying clinical study is not specified.

Freshness

Last updated 2026-04-13 08:51:45; freshness should be verified.

Geography

Data is from a study involving Kenyan adults.