Plasma Cryptococcal Antigen Titers in Uganda from 2017 to 2022

From November 2017 to May 2022, this dataset contains information on 436 adults with advanced HIV disease who had a positive plasma cryptococcal antigen (CrAg) test in Uganda. It was created by Rajasingham, Radha of the Uganda-Minnesota Research Collaboration to evaluate changes in CrAg titers over time with the expansion of national screening and antiretroviral therapy access. The data includes median CD4+ cell counts, CrAg titers, and ART status for participants.

Use Cases

• Analyzing trends in plasma CrAg titers over time based on quarterly measurements from 2017 to 2022.
• Investigating the relationship between ART status and cryptococcal antigenemia based on participant ART history.
• Modeling predictors of high CrAg titer (>=1:160) based on CD4+ cell count and other clinical variables likely present.
• Evaluating the impact of national screening program rollout on disease presentation based on longitudinal cohort data.

Strengths

• Contains data on 436 patients with positive CrAg tests, providing a substantive cohort.
• Covers a 5-year time period (2017-2022) for longitudinal analysis.
• Includes specific clinical metrics: median CD4+ count of 45 cells/µL and median CrAg titer of 1:80.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• Description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

Uganda-Minnesota Research Collaboration

Collection Method

Prospective screening of adults with advanced HIV disease (CD4<200 cells/µL) using the lateral flow assay.

Time Range

November 2017 to May 2022

Freshness

Last updated 2026-06 05 19:09:04; freshness should be verified

Geography

Uganda