Norwegian Obesity Study: Biomarker Changes After Modest Weight Loss

A Norwegian clinical study of 28 individuals with obesity, with 13 achieving ≥5% weight loss. The dataset underpins a 2019 manuscript investigating changes in insulin resistance, leptin sensitivity, and adipokine ratios following weight loss. It includes results from Oral Fat and Glucose Tolerance Tests conducted at the University Hospital of North Norway.

Use Cases

• Analyzing correlations between weight loss percentage and changes in the leptin to adiponectin ratio.
• Modeling improvements in insulin resistance (HOMA-IR) based on weight loss thresholds.
• Studying postprandial triglyceride response and clearance using Oral Fat Tolerance Test data.
• Investigating changes in indirect leptin sensitivity via the REE:leptin ratio.

Strengths

• Dataset is directly linked to a specific 2019 research manuscript, providing clear context.
• Includes specific biomarker improvement percentages: HOMA-IR (-23.1%), REE:leptin ratio (+80.1%), L:A ratio (-45.7%) for ≥5% weight loss.
• Defines clear participant groups: 28 total, 13 with ≥5% weight loss, and 5 with ≥10% weight loss.

Limitations

• Row count is unknown, which may limit suitability assessment.
• Column-level documentation is absent; field semantics must be inferred after download.
• Data may reflect geographic bias inherent to a single hospital cohort in Norway.

Provenance

Source

DataverseNO Harvested Dataverse, author Victoria Therese Isaksen.

Collection Method

Participants were recruited via posters, hospital patients, and a weight loss program; data collected from clinical visits before and after weight loss.

Time Range

Study period not explicitly stated; manuscript submitted December 2019.

Freshness

Last updated 2024-03-31 10:09:01; freshness should be verified.

Geography

University Hospital of North Norway, Norway.