CDKL5 Inhibitor Characterization: Western Blot and Electrophysiology Data

Data generated for the development and characterization of a specific inhibitor of the serine-threonine kinase CDKL5. The dataset contains western blot images and electrophysiological recordings related to long-term potentiation (LTP) in hippocampal CA1 physiology, ordered with reference to a published manuscript. It was authored by Timothy Benke and hosted on Harvard Dataverse, with a last update timestamp of 2026-05-04.

Use Cases

• Re-quantify kinase inhibition efficacy based on provided western blot images.
• Re-analyze synaptic plasticity effects based on electrophysiological field or whole-cell patch-clamp recordings.
• Validate statistical approaches used in the original manuscript using the structured data files.
• Compare inhibitor specificity for CDKL5 versus cross-talk with other kinases like GSK3β.

Strengths

• Data is explicitly ordered with reference to manuscript figures, facilitating direct comparison with published results.
• Western blot images were obtained with standard imaging techniques, allowing for user re-quantification.
• Raw electrophysiological traces or analyses are provided, enabling independent re-analysis.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count and file size are unknown, which may limit suitability assessment.
• Data reuse is explicitly limited to re-analyses and should not be combined into novel datasets due to variable experimental conditions.

Provenance

Source

Harvard Dataverse

Collection Method

Experimental data from western blots and electrophysiological recordings from neurons in brain slices.

Time Range

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Freshness

Last updated 2026-05-04 23:18:30; freshness should be verified.

Geography

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