Featuring partial 16s rRNA sequence data for 876 children hospitalized with severe pneumonia in East Africa. It includes patients' sociodemographic characteristics, clinical features, and respiratory virus diagnoses, generated as part of the Children's Oxygen Administration Strategies Trial (COAST).
Use Cases
- Analyze associations between nasopharyngeal microbiome composition and clinical outcomes like pneumonia diagnosis and severity.
- Investigate correlations between sociodemographic characteristics and the presence of specific respiratory viruses.
- Examine the relationship between underlying comorbidities and nasopharyngeal microbiome profiles in pediatric patients.
Strengths
- Data is derived from a randomized controlled trial (COAST) involving 876 children.
- Includes both microbiome sequence data and detailed clinical correlates such as symptoms and outcomes.
- Focuses on a specific and severe pediatric condition (severe pneumonia) in a defined geographic region (East Africa).
Limitations
- The specific column structure and file formats are unknown, complicating initial data exploration.
- Sample data is unavailable, preventing assessment of data completeness or value distributions prior to download.
- The dataset is a replication dataset for a specific manuscript, which may limit its scope to the variables analyzed in that study.
Provenance
- Source
- Virus Epidemiology and Control (VEC) Dataverse
- Collection Method
- Partial 16s rRNA sequence data generated on the MiSeq platform, combined with clinical trial records from the COAST study.
- Time Range
- null
- Freshness
- null
- Geography
- East Africa