HIV-Associated Cryptococcal Meningitis Clinical Outcomes in Uganda, 2010-2022

2,022 persons with confirmed cryptococcal meningitis were analyzed across three prospective cohorts spanning 2010 to 2022. The data, from the Uganda-Minnesota Research Collaboration, tracks changes in clinical presentation and mortality, revealing a less severely ill population in the most recent cohort with a 2-week mortality of 13% for trial participants. This dataset supports analysis of the evolving HIV and cryptococcal meningitis landscape following improvements in antiretroviral therapy access.

Use Cases

• Analyze temporal trends in clinical presentation based on cohort comparisons from 2010-2022
• Model predictors of 2-week and 16-week mortality based on baseline demographics and clinical characteristics
• Evaluate the impact of ART status and CD4 count on disease severity and outcomes
• Study changes in cerebrospinal fluid (CSF) metrics and culture results over time

Strengths

• Data covers 2,022 confirmed cases over a 12-year period from 2010 to 2022
• Includes three distinct prospective cohorts allowing for temporal trend analysis
• Tracks specific clinical outcomes including 2-week and 16-week mortality

Limitations

• Column-level documentation is absent; field semantics must be inferred after download
• Row count is unknown, which may limit suitability assessment

Provenance

Source

Uganda-Minnesota Research Collaboration

Collection Method

Analysis of three prospective cohorts of HIV-infected Ugandans with cryptococcal meningitis

Time Range

2010 to 2022

Freshness

Last updated 2026-03-22 19:59:27; freshness should be verified

Geography

Uganda