Replogle-Nadig: CRISPR Screen Differential Expression Statistics for 4 Cell Lines

Replogle-Nadig CRISPR Screen Differential Expression Summary Statistics provide per-gene fold changes, significance, and pseudobulk deltas from a genome-scale CRISPR screen. The data includes results from ~2,000 gene knockdowns across four cell lines: hepg2, jurkat, k562, and rpe1. The dataset was authored by tahoebio and last updated on Hugging Face in June 2026.

Use Cases

• Training models for gene perturbation effect prediction based on summarized fold changes and significance values.
• Benchmarking differential expression analysis methods using pseudobulk deltas derived from single-cell data.
• Studying cell-type-specific responses to CRISPR knockdowns across the four provided cell lines.

Strengths

• Data is derived from a genome-scale CRISPR screen covering ~2,000 gene knockdowns.
• Results are summarized from raw single-cell data, providing per-gene fold changes and significance.
• Includes perturbations across four distinct cell lines: hepg2, jurkat, k562, and rpe1.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count and file size are unknown, which may limit suitability assessment.
• The description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

tahoebio on Hugging Face

Collection Method

Summarized from raw single-cell data from a CRISPR screen.

Freshness

Last updated 2026-06-02 00:53:50; freshness should be verified.