GsOYE Mutant Data for Enantioselective Allenoate Synthesis

A 2026 dataset from figshare by Heli Cheng details the directed evolution of an 'ene'-reductase enzyme. The data likely contains results from repurposing the enzyme GsOYE from Galdieria sulphuraria into isomerases for synthesizing chiral allenoates. The study produced mutants enabling enantiodivergent synthesis and subsequent cycloaddition reactions to create complex polycycles.

Use Cases

• Training models to predict enzyme function based on directed evolution data mentioned in the description
• Analyzing structure-activity relationships for engineered isomerases based on the described mutant panel
• Studying mechanisms of proton transfer catalysis based on the described one- or two-base mechanistic divergence

Strengths

• Data is associated with a 2026 publication, indicating recent research.
• The study describes achieving excellent enantiodivergence and negligible product inhibition.
• The work established a biocatalytic platform for setting axial chirality, a specific chemical outcome.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment.
• The dataset is very small at 11.6 KB, indicating limited scope.

Provenance

Source

figshare, author Heli Cheng

Collection Method

Likely contains experimental data from directed evolution and mechanistic studies.

Freshness

Last updated 2026-03-19 18:33:43; freshness should be verified.