Pinaverium Bromide Antifungal Activity and Synergy Study Data

A research dataset supporting a study on repurposing the antispasmodic drug pinaverium bromide as an antifungal agent against Candida albicans. The data includes in vitro analyses of standalone and synergistic antifungal activity, virulence factor attenuation, and mechanistic insights from murine models. The dataset was authored by Jing Yao and last updated on June 2, 2026.

Use Cases

• Evaluating drug synergy based on described in vitro combination assays with amphotericin B or azoles
• Analyzing virulence factor inhibition based on described data for hyphal formation and biofilm development
• Studying antifungal mechanisms based on described data for mitochondrial function, apoptosis, and iron homeostasis
• Validating therapeutic efficacy based on described murine models of systemic candidiasis

Strengths

• Dataset is 1.8 MB in size, indicating a focused and manageable download.
• Research includes validation in two murine models, suggesting a translational component.
• Data is shared under a permissive CC-BY-4.0 license.

Limitations

• Row count and column-level documentation are unknown, which limits suitability assessment.
• The dataset consists of PDF and DOCX files, suggesting it is primarily documentation rather than structured data tables.
• Description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

figshare

Collection Method

Likely contains experimental results from in vitro assays and murine model studies as described.

Freshness

Last updated 2026-06-02 06:40:05; freshness should be verified.