A fibulin-5 global knockout mouse model investigates the impact of elastic fiber deficiency on cervical contractile and biomechanical behavior. Cervixes from nulliparous fibulin-5 wildtype, haploinsufficient, and deficient mice were subjected to biaxial contractile and biomechanical extension-inflation testing. Immunofluorescence quantified elastin and alpha-smooth muscle actin localization and expression.
Use Cases
- Modeling cervical tissue biomechanics based on biaxial extension-inflation test results
- Analyzing the relationship between elastic fiber deficiency and contractile behavior based on knockout model comparisons
- Correlating protein expression levels with mechanical stability based on immunofluorescence quantification of elastin and alpha-smooth muscle actin
Strengths
- Data is derived from a controlled experimental model using three distinct genotypes (Fbln5+/+, Fbln5+/−, Fbln5−/−)
- Includes multiple measurement modalities: biomechanical testing and immunofluorescence imaging
Limitations
- Column-level documentation is absent; field semantics must be inferred after download
- Row count is unknown, which may limit suitability assessment
Provenance
- Source
- Texas Data Repository Harvested Dataverse
- Collection Method
- Experimental data from ex vivo biaxial testing and immunofluorescence on mouse cervical tissue.
- Time Range
- null
- Freshness
- Last updated 2026-07-20 04:10:09; freshness should be verified
- Geography
- null