Gene expression profiles from a 3-D human skin tissue model exposed to high (2.5 Gy) and low (0.1 Gy) doses of protons. The dataset includes samples at 4, 16, and 24 hours post-exposure with three biological repeats per condition, collected by the National Aeronautics and Space Administration. Data was last updated in March 2026.
Use Cases
- Modeling differential gene expression responses based on radiation dose levels (0.1 Gy vs. 2.5 Gy).
- Analyzing temporal progression of radiation response based on timepoints (4, 16, 24 hours).
- Comparing biological replicates to assess response variability in a 3-D tissue model.
- Studying low-dose radiation effects in a tissue context that may differ from 2-D cell cultures.
Strengths
- Includes three biological repeats for each experimental condition, which may support statistical analysis.
- Compares specific high (2.5 Gy) and low (0.1 Gy) dose exposures across multiple timepoints.
- Uses a 3-D tissue model (EPI-200) designed to imitate human epidermis structure and function.
Limitations
- Column-level documentation is absent; field semantics must be inferred after download.
- Row count is unknown, which may limit suitability assessment for large-scale analysis.
Provenance
- Source
- National Aeronautics and Space Administration
- Collection Method
- Global gene expression profiling via nucleic acid hybridization (inferred from platform tags).
- Time Range
- Samples analyzed at 4, 16, and 24 hours after exposure.
- Freshness
- Last updated 2026-03-13 20:28:16.786971; freshness should be verified.
- Geography
- null