Rhodium-Catalyzed Spirocyclization Data for Trifluoromethyl-Substituted Compounds

Qihua Chen's dataset on figshare details Rh(III)-catalyzed C–H bond activation and [3+3] spirocyclization reactions. The data describes a method for synthesizing a broad spectrum of trifluoromethyl-substituted spiroheterocycles, including benzoxazine and isoquinoline skeletons, with yields up to 98%. The dataset was last updated on April 3, 2026.

Use Cases

• Predicting reaction yields for trifluoromethyl-substituted spiroheterocycle synthesis based on described reaction conditions.
• Training models for molecular property prediction of compounds containing benzoxazine and isoquinoline skeletons.
• Analyzing structure-activity relationships for biologically relevant spiroheterocyclic compounds mentioned in the description.

Strengths

• Describes a method achieving yields up to 98% for synthesized compounds.
• Covers a broad spectrum of spiroheterocycle molecules with structurally diverse trifluoromethyl substitutions.
• Dataset is 21.9 MB, indicating a contained and likely manageable file size.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for statistical modeling.
• Description metadata is limited; actual data quality requires manual inspection after download.

Provenance

Source

Qihua Chen via figshare

Collection Method

Likely contains experimental or computational data from the described chemical synthesis research.

Time Range

null

Freshness

Last updated 2026-04-03 18:03:59; freshness should be verified.

Geography

null