Rhodium-Catalyzed Spirocyclization Reaction Data for Trifluoromethyl Heterocycles

A 23.4 MB dataset from figshare, last updated in April 2026, documents Rh(III)-catalyzed C–H bond activation and [3+3] spirocyclization reactions. The work by Qihua Chen describes the synthesis of structurally diverse trifluoromethyl-substituted spiroheterocycles, including benzoxazine and isoquinoline skeletons, with yields up to 98%.

Use Cases

• Predicting reaction yields for Rh(III)-catalyzed C–H activation based on described reaction conditions.
• Screening for novel bioactive molecules based on the described trifluoromethyl-substituted spiroheterocycle structures.
• Training models to identify spirocyclization pathways based on the described cascade of C–H activation, tautomerization, and nucleophilic addition.

Strengths

• Reaction yields are reported up to 98%, indicating high efficiency for the described method.
• Dataset size is 23.4 MB, suggesting it contains detailed experimental information.
• The description specifies a broad spectrum of synthesized molecules with biologically important skeletons.

Limitations

• Column-level documentation is absent; field semantics must be inferred after download.
• Row count is unknown, which may limit suitability assessment for large-scale statistical analysis.
• Data may reflect methodological bias inherent to the single described synthetic pathway.

Provenance

Source

figshare

Collection Method

Likely contains experimental data from synthetic organic chemistry research.

Time Range

Publication date suggests data reflects work circa 2026.

Freshness

Last updated 2026-04-03 18:04:01; freshness should be verified.

Geography

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