Rim4-Seeded Stress Granule Data in Saccharomyces cerevisiae

This dataset relates to the discovery that stress granule formation, seeded by the meiosis-specific RNA binding protein Rim4, halts meiosis at high temperatures in Saccharomyces cerevisiae. It explores the temperature range for meiotic stress granule appearance (33–42 °C) and the role of proteins like 14-3-3 and Hsp104 in assembly and disassembly. The data connects granule persistence to recovery, suggesting a role in cellular repair.

Use Cases

• Analyze the correlation between stress granule persistence duration and meiotic recovery outcomes.
• Model the temperature-dependent dephosphorylation of Rim4 and its role in stress granule seed formation.
• Investigate the interaction dynamics between Rim4, Pab1, and recruited mRNAs under heat stress conditions.
• Compare the temperature thresholds for stress granule formation in meiotic (33–42 °C) versus mitotic (~46 °C) contexts.

Strengths

• Research is grounded in a specific biological model organism, Saccharomyces cerevisiae.
• Identifies a precise temperature range (33–42 °C) for the observed meiotic stress granule phenomenon.
• Proposes a detailed mechanistic pathway involving Rim4 dephosphorylation, 14-3-3 proteins, and Hsp104.

Limitations

• The specific data format, size, and variables (columns) are not described.
• The dataset's applicability is limited to the studied biological system and may not generalize directly to other species.
• Recency of the underlying experimental data is unclear, though the record was updated in 2026.

Provenance

Source

Texas Data Repository Harvested Dataverse

Collection Method

Experimental research in Saccharomyces cerevisiae, as described in the associated study.

Freshness

Record last updated on 2026-02-09.