Secondary analysis of the Global PARITY study, focusing on 763 children admitted with hypoxemia from a total cohort of 7,538. It examines associations between mortality, respiratory care resource availability, and the presence of PARDS triggers like pneumonia and sepsis.
Use Cases
- Analyze the association between mortality and the five-tiered respiratory care resource bundle availability at treatment sites.
- Investigate the prevalence and mortality outcomes of specific PARDS triggers, such as pneumonia, bronchiolitis, and sepsis, among hypoxemic children.
- Model the adjusted odds ratio for mortality in patients treated at sites with intermediate or less resource bundles compared to advanced or expert bundles.
- Examine the proportion of patients with a PARDS trigger who had insufficient data for a PARDS diagnosis according to PALICC-2 guidelines.
Strengths
- Derived from the substantial Global PARITY cohort of 7,538 pediatric patients.
- Focuses on a clinically significant sub-cohort of 763 children with hypoxemia.
- Includes analysis of specific clinical triggers (pneumonia, bronchiolitis, sepsis) and resource availability tiers.
Limitations
- A secondary analysis, not primary data collection, which may limit variable availability.
- The study notes that 94% of patients with a PARDS trigger had insufficient data for a formal PARDS diagnosis.
- Geographic and resource-setting focus may limit generalizability to high-resource contexts.
Provenance
- Source
- Secondary analysis of the Global Paediatric Acute Critical Illness Point Prevalence Study (PARITY).
- Collection Method
- Descriptive statistics, hypothesis testing (chi-square, Wilcoxon rank-sum), and logistic regression on deidentified patient data.
- Time Range
- null
- Freshness
- null
- Geography
- Resource-constrained settings in countries with lower socio-demographic index (SDI).